I found this spot on my 7 week old kitten, it doesn't seem to be painful. I tried to clean it using H2O2 solution - it went away, but 5 days later appeared again together with a new spot on the nose.
Is it an infection? Should I go to vet?
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The vet said it is feline acne, most likely caused by using plastic plate; it is a kind of allergic reaction to plastic and my kitten was too small to clean itself properly.
First, please switch to using plate made of metal instead of plastic.
Second, the best remedy is to dry it with H2O2 (hydrogen peroxide) solution multiple times for 5-10 minutes, then when it becomes soft try to clean it with dry cotton, but don't scratch the spot. Repeat the process next day until you remove the spot.
My immediate guess was freckles. Really. Orange tabbies have freckles under their fur. Surprised me too when I first noticed on mine, but it's entirely normal.
If it's really something that can be cleaned off, it could be something greasy that the cat is rubbing against, or...
Basic principle: if you are asking "should I go to the doctor/vet", you should. (I spent 24 hours walking around with an atypical heart attack in progress. Don't Do That.)